Cancer Care

Premier Health providers answer frequently asked questions about cancer care for women.

Is there an association between hormone replacement therapy and ovarian cancer?

Dr. Michael Guy explains the relationship between hormone replacement therapy and ovarian cancer. Click play to watch the video or read the transcript.


Hormone replacement therapy, estrogen in particular, may have a moderate effect on one’s risk for ovarian cancer, according to the National Institutes of HealthOff Site Icon (NIH).

The American Cancer SocietyOff Site Icon (ACS) states that studies conducted by Women’s Health Initiative (WHI) on at least two forms of hormone therapy replacement reported these findings:

 Estrogen-progestin therapy (EPT)Estrogen therapy (ET)
Endometrial cancerDoesn’t increase riskDoesn’t increase risk
Breast cancerIncreased riskDoesn’t increase risk
Ovarian cancerSlight increase of riskNo findings

For more information about hormone replacement therapy and ovarian cancer, ask your doctor.

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Michael S. Guy, MD

Michael S. Guy, MD

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Source content: Tracie Bolden, MD, Fairfield Road Physician Offices; Thomas Heck, MD, FACS, Gem City Surgical Associates; Todd Hicks, MD, FACS, Premier Plastic Surgeons; Christopher Lutman, MD, Premier Gynecologic Oncology; Michael Guy, MD, Premier Gynecologic Oncology