Gynecologic Cancer

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A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First-Line Treatment of BRCA non-mutated Advanced Epithelial Ovarian Cancer (EOC) (KEYLYNK-001 / ENGOT-ov43)

The purpose of this study is to assess the efficacy and safety of treatment with carboplatin/paclitaxel PLUS pembrolizumab (MK-3475) and maintenance olaparib (MK-7339) in women with epithelial ovarian cancer (EOC), fallopian tube cancer, or primary peritoneal cancer.

Study Details

  • Study Site/Tumor Location: Gynecologic Cancer
  • Study Location: Miami Valley Hospital South Campus
  • Ages eligible for study: 18 years and older
  • Genders eligible for study: Female
  • Principal Investigator: Dr. Michael Guy
  • Other Physicians who can consent: Dr. Guy, Dr. Reid, Dr. Ore

Study Contact Information

NRG-CC004 Double Blind Dose Finding Trial of Bupropion Vs Placebo for Sexual Desire in Women with Breast or Gynecologic Cancer

Study Details

  • Study Site/Tumor Location: Breast Cancer (Post-Menopausal)
  • Study Location: All Premier
  • Ages eligible for study: 18 years and older
  • Genders eligible for study: Female
  • Principal Investigator: Dr. Gross
  • Other Physicians who can consent: Dr. Bane, Dr. Cheruvu, Dr. Ditzel, Dr. Guy, Dr. Jilani, Dr. Kathula, Dr. Koduri, Dr. Marinella, Dr. Miller, Dr. Okoye, Dr. Rajsheker, Dr. Romer, Dr. Sabagh, Dr. Setzkorn, Dr. Sheth, Dr. Steinmetz

Study Contact Information

NRG-GY005 Cediranib + Olaparib combined vs Cediranib or Olaparib alone, or standard of care chemo, recurrent platinum resistant or refractory ovarian, fallopian or primary peritoneal ca.

Study Details

  • Study Site/Tumor Location: Gynecology
  • Study Location: Miami Valley Hospital South Campus
  • Ages eligible for study: 18 years and older
  • Genders eligible for study: Female
  • Principal Investigator: Dr. Gross
  • Other Physicians who can consent: Dr. Bane, Dr. Cheruvu, Dr. Ditzel, Dr. Guy, Dr. Jilani, Dr. Kathula, Dr. Koduri, Dr. Marinella, Dr. Miller, Dr. Okoye, Dr. Rajsheker, Dr. Romer, Dr. Sabagh, Dr. Setzkorn, Dr. Sheth, Dr. Steinmetz

Study Contact Information

NRG-GY006 RT and Cisplatin +/- intravenous Triapine, new diagn. bulky stage IB2, stage II, IIB or IVA ca. uterine cervix or stage II-IVA vag.l ca.

Study Details

  • Study Site/Tumor Location: Gynecology
  • Study Location: Miami Valley Hospital South Campus
  • Ages eligible for study: 18 years and older
  • Genders eligible for study: Female
  • Principal Investigator: Dr. Gross
  • Other Physicians who can consent: Dr. Bane, Dr. Cheruvu, Dr. Ditzel, Dr. Guy, Dr. Jilani, Dr. Kathula, Dr. Koduri, Dr. Marinella, Dr. Miller, Dr. Okoye, Dr. Rajsheker, Dr. Romer, Dr. Sabagh, Dr. Setzkorn, Dr. Sheth, Dr. Steinmetz

Study Contact Information

NRG-GY007 Ruxolitinib with Front-Line Neoadj. and Post-Surgical TX in Adv. Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Details

  • Study Site/Tumor Location: Gynecology
  • Study Location: Miami Valley Hospital South Campus
  • Ages eligible for study: 18 years and older
  • Genders eligible for study: Female
  • Principal Investigator: Dr. Gross
  • Other Physicians who can consent: Dr. Bane, Dr. Cheruvu, Dr. Ditzel, Dr. Guy, Dr. Jilani, Dr. Kathula, Dr. Koduri, Dr. Marinella, Dr. Miller, Dr. Okoye, Dr. Rajsheker, Dr. Romer, Dr. Sabagh, Dr. Setzkorn, Dr. Sheth, Dr. Steinmetz

Study Contact Information

NRG-GY014 Tazemetostat in Recurrent or Persistent Endometrioid or Clear Cell Ca of the Ovary, and Recurrent or Persistent Endometrioid Endometrial Adenocarcinoma

Study Details

  • Study Site/Tumor Location: Gynecology
  • Study Location: Miami Valley Hospital South Campus
  • Ages eligible for study: 18 years and older
  • Genders eligible for study: Female
  • Principal Investigator: Dr. Gross
  • Other Physicians who can consent: Dr. Bane, Dr. Cheruvu, Dr. Ditzel, Dr. Guy, Dr. Jilani, Dr. Kathula, Dr. Koduri, Dr. Marinella, Dr. Miller, Dr. Okoye, Dr. Rajsheker, Dr. Romer, Dr. Sabagh, Dr. Setzkorn, Dr. Sheth, Dr. Steinmetz

Study Contact Information